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For example, in clinical trials of semaglutide 2.4 mg (Wegovy), nausea occurred in approximately 44% of patients, while rates for tirzepatide and other GLP-1s vary: Nausea : Often described as mild queasiness, particularly after eating, though some patients experience more pronounced nausea Bloating and abdominal fullness : A sensation of delayed digestion or food sitting heavily in the stomach Changes in bowel habits : Constipation affects approximately 15-30% of patients (varying by medication and dose), while some experience diarrhea or alternating patterns [1] [4] Decreased appetite : Beyond simple fullness, many report a fundamental shift in food thoughts, with reduced cravings and less mental preoccupation with eating Some patients report fatigue or low energy , particularly during the initial weeks

GLP-1 receptor agonists made the shortlist after SGLT2 inhibitors, metformin and the osteoporosis drug, bisphosphonates

That growth is great for access, but it also makes picking the best online GLP-1 program harder than it should be

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Blood sugar changes: If you were using the medication for diabetes or insulin resistance, you might see blood sugar spikes or dips